Scientific Program

Conference Series Ltd invites all the participants across the globe to attend International Conference on Neurooncology and Neurosurgery Dubai, UAE.

Day 2 :

OMICS International Neurooncology Surgery 2018 International Conference Keynote Speaker Sebouh Kassis photo
Biography:

Sebouh Kassis is a Neurosurgeon and Spine Surgeon. He has completed his Neurosurgical training from the University Hospital of Liege in Belgium where he was graduated with the Highest Distinction Award and became holder of Belgian Board Certificate in Neurosurgery. He has also completed a Fellowship program of 3 years in the Neurological Hospital of Lyon, France and is a holder of French Specialty Certificate for both Neurosurgery and Neurology. He has special interest and expertise in the treatment of pituitary and skull base pathologies with fully endoscopic approaches, microsurgical and minimally invasive treatment of diverse spinal pathologies, spinal fusion including deformity correction. He has also committed to the integration of spinal navigation and neurophysiology monitoring in the management of complex spine cases. He is the Head of the Neurosurgery Department of Al Zahra Private Hospital, Dubai.
 

Abstract:

Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNETs) represent about half of all pituitary neuroendocrine tumors. Being clinically silent, NF-PitNETs are usually discovered as macroadenomas compressing the optic chiasma, the pituitary gland or/and the pituitary stalk. Surgical removal remains the treatment of choice considering almost the absence of an effective medical treatment in contrast to most functioning pituitary tumors. Although the vast majority of NF-PitNETs are benign, their treatment remains a challenge considering that about 50% present with cavernous sinus invasion at the time of diagnosis which limits the radical removal. It is estimated that about half of the patients with invasive NF-PitNETs present regrowth of the residual tumor and about 15% present growth after gross total removal without residue. Inspired from the recent 2017 WHO classification and numerous studies, the term (high risk pituitary adenoma) evolved in the recent years; this includes tumors with increased cell proliferation and signs of invasive growth evaluated by MRI and/ or histology. Subsequently, the optimal treatment strategy of NF-PitNETs nowadays should not only consider the choice of surgical technique but also identifying factors which help predicting the risk of recurrence. In this presentation, the author exposes the current surgical techniques and discusses the predictive factors of recurrence and the different management modalities in such cases.
 

Keynote Forum

Gajendra Prasad Rauniar

B.P.Koirala Institute of Health Sciences, Nepal

Keynote: Therapeutic drug monitoring of antiepileptic drugs in BPKIHS, Dharan

Time : 09:50-10:40

OMICS International Neurooncology Surgery 2018 International Conference Keynote Speaker Gajendra Prasad Rauniar photo
Biography:

Gajendra Prasad Rauniar is currently working as a Professor in the Department of Clinical Pharmacology and Therapeutics at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. He has published more than 60 scientific papers in national and international journals. He is currently doing research in neuropharmacology related clinical trials as well as drug utilization. 

Abstract:

Background & Aim: Epilepsy is the second most common neurological disorder. Phenytoin, Carbamazepine and Lamotrigine are regularly prescribed. The success of antiepileptic therapy depends on careful dosage titration based on desired patient response and Therapeutic Drug Monitoring (TDM). The objective of the study is to see the socio-demographic profile of epileptic patients on Phenytoin, Carbamazepine and Lamotrigine and to categorize epileptic patients on Phenytoin, Carbamazepine and Lamotrigine into sub-therapeutic, therapeutic and above-therapeutic.
 
Method: It was observational, cross-sectional study performed in BPKIHS. Blood samples was collected, immediately centrifuged, plasma separated and stored at -20ºC . Later it was vortexed and centrifuged at room temperature. Suitable extractive solvent was used for extraction of the selected drugs from plasma; organic layer aspirated and evaporated to dryness in hot water bath maintained at 400ºC using gentle steam of Nitrogen. Extracted residue was reconstituted in mobile phase and injected into previously validated and calibrated HPLC system for particular drug. Data collected were entered in excel sheet and analyzed with IBM SPSS Software. Ethical clearance was obtained from Institutional Review Committee (IRC) of BPKIHS.
 
Result: Among 42 selected patients, Male: Female ratio was 4:3. Most patients were of age group (15-45 years). Most were students from Sunsari district. Seizure started at birth in 23.8%. Most seizures were idiopathic. GTCS was the most common diagnosis made. Phenytoin was the most commonly used drug (50%) followed by carbamazepine (40%) and Lamotrigine (10%). Phenytoin was sub-therapeutic in 28.6%, therapeutic in 71.4% and above therapeutic in none. Carbamazepine was sub therapeutic in 13.8%, therapeutic in 82.4% and above therapeutic in 11.8%. Lamotrigine was sub therapeutic in 50% and therapeutic in 50% cases.
 
Conclusion: TDM was therapeutic in 73.8%, sub therapeutic in 21.4% and above therapeutic in 4.8%.
 

Keynote Forum

Hischam Bassiouni

Klinikum St. Marien Amberg, Germany

Keynote: Lesion-tailored approaches in spinal surgery

Time : 11:00-11:50

OMICS International Neurooncology Surgery 2018 International Conference Keynote Speaker Hischam Bassiouni  photo
Biography:

Hischam Bassiouni is an Associate Professor of Neurosurgery. He is the Director of two Neurosurgical Clinics at two major academic teaching hospitals, (Klinikum Amberg and Klinikum Weiden) in Bavaria, Germany. He is also the Member of German Neurosurgical Society, European Neurosurgical Society and German Skull Base Society. He had his Neurosurgical training at University Hospital Aachen and University Hospital Essen, Germany. His neurosurgical and scientific sub-specializations include neuro-oncology, neurovascular surgery, skull base surgery and neuro-pediatric surgery. He is the first author of 13 publications in highranked Neurosurgical journals and has authored several chapters in international neurosurgical reference books.
 

Abstract:

Different approaches for the resection of spinal intradural tumors are used including laminectomy, laminoplasty, hemilaminectomy, etc. In order to reduce spinal surgical trauma and simultaneously achieve complete resection of the lesion with decompression of neural structures we perform minimal invasive lesion-tailored approaches. In this presentation we demonstrate minimal invasive approaches at different spinal levels to various spinal lesions focusing primarily on intradural tumors. Accurate pre-operative planning and meticulous intra-operative microsurgical technique permits treatment of spinal lesions via least invasive surgical approaches. Lesion-tailored microsurgical approaches help to preserve spinal biomechanical integrity, permit complete resection of spinal tumorous lesions with restoration of neural function.